<menuitem id="hj9zb"><sub id="hj9zb"></sub></menuitem>
<pre id="hj9zb"></pre>

<pre id="hj9zb"><sub id="hj9zb"><th id="hj9zb"></th></sub></pre>
<pre id="hj9zb"><sub id="hj9zb"><th id="hj9zb"></th></sub></pre>

<menuitem id="hj9zb"><sub id="hj9zb"></sub></menuitem>
<pre id="hj9zb"><sub id="hj9zb"><track id="hj9zb"></track></sub></pre>
<menuitem id="hj9zb"><sub id="hj9zb"></sub></menuitem>
<pre id="hj9zb"></pre>

<menuitem id="hj9zb"><sub id="hj9zb"></sub></menuitem><pre id="hj9zb"><sub id="hj9zb"><track id="hj9zb"></track></sub></pre>

<menuitem id="hj9zb"><address id="hj9zb"></address></menuitem>
<pre id="hj9zb"></pre>

<pre id="hj9zb"><sub id="hj9zb"><th id="hj9zb"></th></sub></pre>

<mark id="hj9zb"><sub id="hj9zb"></sub></mark>

<pre id="hj9zb"><sub id="hj9zb"><th id="hj9zb"></th></sub></pre><dl id="hj9zb"></dl>
<dl id="hj9zb"><address id="hj9zb"><track id="hj9zb"></track></address></dl>

點擊這里聯系客服肖月
肖月
點擊這里聯系客服劉科
劉科
點擊這里聯系客服楊廣蘭
楊廣蘭
點擊這里聯系客服張歡
張歡
首頁 > 文章詳細

Chlorogenic acid ameliorates mice clinical endometritis ...

發布日期:2021-09-27 16:53:52 【關閉】
摘要:Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NF

期刊名:Journal of Pharmacy and Pharmacology
期刊網址:https://pubmed.ncbi.nlm.nih.gov/33734387/
發表日期:18 March 2021bstract
Objectives Clinical endometritis is a common reproductive disorder in mammals that seriously
endangers animal health and causes economic losses worldwide. This study aims to use lipopoly
saccharide and Trueperella pyogenes exotoxin as modelling reagents (LC) to perfuse the mouse
uterus in order to establish a model of clinical endometritis and to investigate the anti-inflamma
tory and antioxidant effects of chlorogenic acid (CGA).
Methods In this study, five LC uterine perfusions were selected to model clinical endomet
ritis. The anti-inflammatory and antioxidant effects of CGA were clarified. Through HE staining,
proinflammatory cytokines, blood testing, NFκB and Keap1/Nrf2 signalling pathways and other
index changes to explore the protection mechanism of CGA.
Key findings After CGA treatment, the appearance, inflammatory damage and blood indicators of
the mouse uterus returned to normal. Simultaneously, CGA could inhibit the activation of NFκB
and reduce the release of inflammatory cytokines; CGA could also activate Keap1/Nrf2, promote
the dissociation of Keap1 and Nrf2 and significantly increase the expression of the downstream
genes HO-1 and NQO1.
CGA (purity >98.0%) was purchased from Desite Bio (Chengdu, 
China).


18禁止看到的黄色网站_18禁止看的黄网站_18禁止看的免费污网站